Name | Ethyl Oleate |
Synonyms | oleic FEMA 2450 ETHYL OLEATE Ethyl Oleate Ethyl oleate (OA-EE) ethyl octadec-9-enoate ETHYL (Z)-9-OCTADECENOATE ethyl (9Z)-octadec-9-enoate ethyl (9E)-octadec-9-enoate Ethyl oleate, mixture of isomers (Z)-9-Octadecenoicacidethylester 9-Octadecenoicacid(Z)-,ethylester (Z)-9-Octadecenoic acid ethyl ester 9-Octadecenoic acid (Z)-, ethyl ester |
CAS | 111-62-6 |
EINECS | 203-889-5 |
InChI | InChI=1/C20H38O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-4-2/h11-12H,3-10,13-19H2,1-2H3/b12-11+ |
InChIKey | LVGKNOAMLMIIKO-VAWYXSNFSA-N |
Molecular Formula | C20H38O2 |
Molar Mass | 310.51 |
Density | 0.87g/mLat 25°C(lit.) |
Melting Point | −32°C(lit.) |
Boling Point | 216-218°C15mm Hg |
Specific Rotation(α) | n20/D 1.451 (lit.) |
Flash Point | >230°F |
JECFA Number | 345 |
Solubility | chloroform: soluble 10%. Insoluble in water, mixed with ethanol and ether. |
Vapor Presure | 3.67E-06mmHg at 25°C |
Appearance | Transparent light yellow oily liquid |
Color | Clear |
Merck | 14,6828 |
BRN | 1727318 |
Storage Condition | -20°C |
Sensitive | Light Sensitive |
Refractive Index | n20/D 1.451(lit.) |
MDL | MFCD00009579 |
Physical and Chemical Properties | Colorless to pale yellow oily liquid. It is fragrant with flowers. Boiling point 205-208 °c. Insoluble in water, soluble in ethanol and acetaldehyde. |
Use | For the preparation of surfactants and other organic chemicals, also used as a fragrance |
Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
WGK Germany | 2 |
RTECS | RG3715000 |
FLUKA BRAND F CODES | 10-23 |
TSCA | Yes |
HS Code | 29161900 |
Raw Materials | Ethyl Alcohol Oleic acid |
Reference Show more | 1. Wang Zhangjie Hu Rongfeng Wang Guokai et al. Box-Behnken Design-Effect Surface Methodology to Optimize Naringenin Self-microemulsion Drug Administration System [J]. Chinese Herbal Medicine 2014 45(17):2461-2466. 2. Wang Zhangjie Liu Ziping Xu Yan et al. Preparation of Candle Leaf Total Flavonoids Microemulsion Gel [J]. Journal of Chifeng University (Natural Edition) 2018 v.34;No.282(02):35-37. 3. Hu Chunli, Yang Beibei, Zhang Linjie, et al. Preparation and Quality Control of Lutein Self-microemulsion [J]. Today's Pharmaceutical 2019(9). 4. Wang Zhangjie, Shi Lingli, Hua Fang, et al. Optimization of Naringenin Inclusion Self-microemulsion Drug Delivery System by Star Point Design-Effect Surface Methodology [J]. Journal of Food and Biotechnology, 2017, 36(003):310-314. 5. Han Bing, Guan Yanbin, Tian Yudong, et al. Preparation and in vitro evaluation of berberine hydrochloride self-microemulsion drug release system [J]. Chinese herbal medicine, 2018, 041(010):2398-2402. 6. Lu Wenqin, Liu Kaiping, Cheng Shengyong, et al. Preparation and in vitro evaluation of solid self-microemulsion of total valerian triester of spider fragrance [J]. Chinese herbal medicine, 2019(4). 7. Liu Kaiping, Cheng Shengyong, Yu Linna, et al. Preparation and quality evaluation of self-microemulsion of total valerian triester from spider fragrance [J]. Chinese Journal of Experimental Presentation, 2018(11):16-21. 8. Xu Kunyong, Shi Yujie, Mei Yanfei, Yan Juan, Yun Guoping. Preparation and in vitro release of naringin microemulsion gel [J]. Research and Practice of Modern Traditional Chinese Medicine, 2020,34(05):55-58 81. 9. Xu Kunyong, Guo Jianzhong, Yan Juan, Yun Guoping. Study on Preparation Technology of Naringin Microemulsion [J]. China Pharmaceutical, 2020,29(23):36-40. 10. Chen, Huimin, et al. "Interaction among protein, daidzein and surfactants in the WPI-based daidzein self-microemulsifying delivery system." Food Chemistry 332 (2020): 127461.https://doi.org/10.1016/j.foodchem. 2020.127461 11. [IF=9.147] Fujia Yang et al."Self-microemulsifying delivery system of WPI-Dai nanocomplex mixed with nonionic surfactant and its superiority in delivering daidzein."Food Hydrocolloid. 2020 Nov;108:105952 12. [IF=6.321] Yujie Zheng et al."Microemulsion Delivery System Improves Cellular Uptake of Genipin and Its Protective Effect against Aβ1-42-Induced PC12 Cell Cytotoxicity."Pharmaceutics. 2022 Mar;14(3):617 |
This product is a mixture of fatty acid ethyl ester, the main component is ethyl oleate.
The relative density of this product (General 0601) is 0. 866~0, 874.
The refractive index of the product (General 0622) is 1. 443-1. 450 at 25°C.
The acid value of this product (General rule 0713) shall not exceed 0. 5.
The saponification value of this product (General 0713) is 177~188.
The iodine value of this product (General 0713) is 75~90.
The peroxide value of this product (General 0713) shall not exceed 10.0.
take l_0 g of this product, put it in a 25 m l round bottom flask, Add 10ml of anhydrous methanol and 6% potassium hydroxide in methanol solution 0. 2ml, connect the reflux condenser tube, at the same time, fill with nitrogen at a flow rate of 50ml per minute, shake, heat to boiling, after the solution is clear (usually need to heat and boil for 10 minutes), continue to heat for 5 minutes, the flask was cooled with water and the contents were transferred to a separatory funnel for quantification. Wash the flask with heptane 5M l, combine the washing solution in the separatory funnel, shake, add 20% sodium chloride solution 10ml, vigorously shake, stand, take the organic layer with anhydrous
The sodium sulfate was dried, filtered, and the filtrate was taken as a test solution. Test according to Gas chromatography (General 0521). Polyethylene glycol was used as the stationary liquid, the initial temperature was 160°C, the temperature was raised to 230°C at a rate of 3°C per minute, the temperature of the injection port was 250°C, and the temperature of the detector was 250°C. Take the test solution 1 (I. E., 1 injection gas chromatograph) and record the chromatogram. According to the area normalization method, the oleic acid (based on methyl oleate) shall not be less than 60.0%. Solvent peaks and chromatographic peaks with a peak area of less than 0.05% are negligible.
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 1 .0%.
not over 0841 (general rule).
pharmaceutical excipients, plasticizers and ointment base.
light shielding, closed storage.
FEMA | 2450 | ETHYL OLEATE |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
toxicity | GRAS(FEMA;FDA,§ 172.515,2000). |
usage limit | FEMA(mg/kg): beverage, ice cream, gelatin and pudding 0.10; Candy 40; Baked products 55. Moderate limit (FDA,§ 172.515,2000). |
use | GB 2760-1996 specified as allowed edible spices. Used as lubricant, water repellent, resin toughening agent. It is used for the preparation of surfactants and other organic chemicals, as well as spices, pharmaceutical excipients, plasticizers and ointment substrates. Lubricant. Water repellent. Resin toughening agent. Gas chromatography stationary solution (maximum service temperature 120 ℃, solvent methanol and ether). Used as a toughening agent for gas chromatography stationary liquid, solvent, lubricant and resin |
production method | is obtained by esterification of oleic acid and ethanol. Sulfuric acid was added to the ethanol solution of oleic acid and heated and refluxed for 10 hours. Cooling, neutralizing with sodium methoxide until pH8-9, washing with water to neutral, adding anhydrous calcium chloride to dry, filtering to obtain ethyl oleate. |